LA POESIA ITALIANA PER L\u2019INFANZIA IN ITALIA DAL 1945 A OGGI. RIFLESSIONI CRITICHE, TESTI, ILLUSTRAZIONI. PROPOSTA DI ANTOLOGIA.

Tracciare un quadro completo della produzione e degli orientamenti della letteratura dell\u2019infanzia dagli inizi del secolo al secondo dopoguerra sarebbe impossibile in questa sede e si rinvia per un quadro dettagliato di autori e opere al volume di Pino Boero e Carmine De Luca, La letteratura per l\u2019infanzia, del 1995, pi\uf9 volte ristampato, e che a tutt\u2019oggi, insieme agli studi specifici di Anna Ascenzi, Antonio Faeti, Angelo Nobile ed altri, rimane il pi\uf9 completo saggio cronologico sulla questione. 1 Tuttavia, per comprendere la portata del rinnovamento e dei cambiamenti avvenuti nella letteratura e nella poesia destinata ai bambini e ai giovani, a partire dal 1945, \ue8 necessario fare riferimento a un ineludibile inquadramento storico e culturale e ricordare alcuni dei momenti pi\uf9 significativi a partire dagli ultimi anni dell\u2019Ottocento, rinviando poi un ulteriore approfondimento relativo soprattutto al periodo che va dagli anni Settanta a oggi, ai singoli capitoli del presente lavoro..

L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

SummaryMetabolites are emerging as key mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. We found that the nonessential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells. This embryonic-stem-cell-to-mesenchymal-like transition (esMT) is accompanied by a genome-wide remodeling of the H3K9 and H3K36 methylation status. Consistently, L-Pro-induced esMT is fully reversible either after L-Pro withdrawal or by addition of ascorbic acid (vitamin C), which in turn reduces H3K9 and H3K36 methylation, promoting a mesenchymal-like-to-embryonic-stem-cell transition (MesT). These findings suggest that L-Pro, which is produced by proteolytic remodeling of the extracellular matrix, may act as a microenvironmental cue to control stem cell behavior

Italian Poetry for the Childwood in Italy from 1945 to today : critical reflections, textes, illustrations. Anthological proposal

Une analyse détaillée de la poésie pour enfants en Italie dans une direction multidisciplinaire (historique, thématique, rhétorique, pédagogique, sociologique) n’avait jamais été réalisée ni commencée jusqu’à aujourd’hui. Le présent ouvrage est donc le premier à prendre en considération une gamme chronologique suffisamment large - de 1945 à nos jours - qui traitent de problèmes éparpillés dans les différents chapitres de littératures pour enfants ou dans des articles de revues spécialisées. Malgré le grand intérêt que l’industrie de l’édition a manifesté dans le passé (au moins depuis les années 60) et continue de démontrer aujourd’hui au public d’enfants, et malgré la richesse et la variété des collections dédiés à la création de poésie et de poésie, l’absence d’ un étude générale nous a paru une grave lacune. L’absence de critique systématique s’explique peut-être par le peu de prestige qui, aujourd’hui malgré tout, recouvre l’écriture destinée aux enfants, comme si l’écriture pour enfants n’était qu’un prélude à la “vraie” écriture et que la poésie pour enfants (considerée comme “simplifiée”) n’était qu’une condition préalable de la “vraie” poésie.Nous pensons donc tout d’abord avoir démontré l’importance de la poésie dans l’enfance même et de sa grande importance dans le processus d’éducation et d’éducation esthétique. A notre avis, la critique ne peut en effet pas être soumise à des principes didactiques ou moraux, mais doit tenir compte de cette démarche artistique : le recueil de poésie pour enfants doit donc satisfaire ses besoins (curiosité, jeu, besoin de s’exprimer) et constituent en même temps un véritable pont entre l’art, la littérature et la musique. L’apport de disciplines telles que la sociologie, en particulier les réflexions sur la société et la culture dites “liquides” théorisées par Zygmunt Bauman ont enrichi les élaborations proposées.Une autre nouveauté est d’avoir mené une étude sur le genre dans le domaine de la poésie de l’enfance. Bien que non définitive, cette enquête nous a permis d’élargir l’horizon de la critique.Dans le contexte des auteurs, nous pensons avoir eu le mérite de nous rappeler des auteurs peu présents (ou totalement absents) dans les anthologies de poésie pour enfants, tels que Tommaso Landolfi, Giulia Niccolai, Rossana Ombres et Giovanni Arpino et pour avoir revendiqué et réservé espace particulier à Giuseppe Pontremoli et Pierluigi Cappello. Dans le contexte des anthologies, nous pensons également, à juste titre, que nous avons inclus l’analyse (et l’évaluation) d’anthologies pour enfants dans l’étude de l’anthologie poétique (en particulier celles de Roberto Antonelli dans « Critica del testo » et Niccolò Scaffai), une opération complètement nouvelle. L’anthologie proposée suit donc les critères mis en évidence et diffère considérablement de celles du passé et de celles actuellement sur le marché.A detailed analysis of poetry for children in Italy in a multidisciplinary direction (historical, thematic, rhetorical, pedagogical, sociological) had never been carried out, nor started until today. The present work is therefore the first that takes into consideration a sufficiently wide chronological range - from 1945 to the present - dealing with issues that were found scattered in the various chapters of literatures for children or in articles in specialized magazines. Despite the great interest that the publishing industry has shown in the past (at least since the Sixties onwards) and still demonstrates today towards the public of children, and despite the richness and variety of necklaces dedicated to the creation of poetry and poetry, the lack of a general study seemed to us a serious gap. The absence of a systematic critique can perhaps be explained by the little prestige that still today, despite everything, covers the writing intended for children, as if writing for children were only a prelude to “true” writing, and poetry addressed to children a simple (and simplified) premise of “true” poetry.We therefore think, first of all, of having demonstrated the importance of poetry for childhood in itself and its great significance in the process of education and aesthetic education. In our opinion, the criticism cannot in fact be subjected to didactic or moral principles, but must take into account this artistic approach : the poetry book for children must therefore satisfy its needs (curiosity, play, the need to express oneself ) and at the same time constitute a real bridge to art, literature and music. The contribution of disciplines such as sociology, in particular the reflections on the so-called “liquid” society and culture theorized by Zygmunt Bauman have enriched the proposed elaborations.Another innovation is that of having carried out a gender study in the field of childhood poetry. Although not definitive, this survey has allowed us to broaden the horizon of criticism.In the context of the authors we think we have had the merit of remembering authors who are not very present (or completely absent) in the anthologies of poetry for children, such as Tommaso Landolfi, Giulia Niccolai, Rossana Ombres and Giovanni Arpino and for having claimed and reserved one particular space to Giuseppe Pontremoli and Pierluigi Cappello. In the context of anthologies, we also rightly believe that we have included the analysis (and evaluation) of children’s anthologies in the study of poetic anthology (in particular those by Roberto Antonelli in « Critica del testo » and Niccolò Scaffai), a completely new operation. The proposed Anthology therefore follows the highlighted criteria and differs considerably from those of the past as well as those currently on the market

La poesia italiana per l’infanzia in italia dal 1945 a oggi : riflessioni critiche, testi, illustrazioni. Proposta di antologia

A detailed analysis of poetry for children in Italy in a multidisciplinary direction (historical, thematic, rhetorical, pedagogical, sociological) had never been carried out, nor started until today. The present work is therefore the first that takes into consideration a sufficiently wide chronological range - from 1945 to the present - dealing with issues that were found scattered in the various chapters of literatures for children or in articles in specialized magazines. Despite the great interest that the publishing industry has shown in the past (at least since the Sixties onwards) and still demonstrates today towards the public of children, and despite the richness and variety of necklaces dedicated to the creation of poetry and poetry, the lack of a general study seemed to us a serious gap. The absence of a systematic critique can perhaps be explained by the little prestige that still today, despite everything, covers the writing intended for children, as if writing for children were only a prelude to “true” writing, and poetry addressed to children a simple (and simplified) premise of “true” poetry.We therefore think, first of all, of having demonstrated the importance of poetry for childhood in itself and its great significance in the process of education and aesthetic education. In our opinion, the criticism cannot in fact be subjected to didactic or moral principles, but must take into account this artistic approach : the poetry book for children must therefore satisfy its needs (curiosity, play, the need to express oneself ) and at the same time constitute a real bridge to art, literature and music. The contribution of disciplines such as sociology, in particular the reflections on the so-called “liquid” society and culture theorized by Zygmunt Bauman have enriched the proposed elaborations.Another innovation is that of having carried out a gender study in the field of childhood poetry. Although not definitive, this survey has allowed us to broaden the horizon of criticism.In the context of the authors we think we have had the merit of remembering authors who are not very present (or completely absent) in the anthologies of poetry for children, such as Tommaso Landolfi, Giulia Niccolai, Rossana Ombres and Giovanni Arpino and for having claimed and reserved one particular space to Giuseppe Pontremoli and Pierluigi Cappello. In the context of anthologies, we also rightly believe that we have included the analysis (and evaluation) of children’s anthologies in the study of poetic anthology (in particular those by Roberto Antonelli in « Critica del testo » and Niccolò Scaffai), a completely new operation. The proposed Anthology therefore follows the highlighted criteria and differs considerably from those of the past as well as those currently on the market.Une analyse détaillée de la poésie pour enfants en Italie dans une direction multidisciplinaire (historique, thématique, rhétorique, pédagogique, sociologique) n’avait jamais été réalisée ni commencée jusqu’à aujourd’hui. Le présent ouvrage est donc le premier à prendre en considération une gamme chronologique suffisamment large - de 1945 à nos jours - qui traitent de problèmes éparpillés dans les différents chapitres de littératures pour enfants ou dans des articles de revues spécialisées. Malgré le grand intérêt que l’industrie de l’édition a manifesté dans le passé (au moins depuis les années 60) et continue de démontrer aujourd’hui au public d’enfants, et malgré la richesse et la variété des collections dédiés à la création de poésie et de poésie, l’absence d’ un étude générale nous a paru une grave lacune. L’absence de critique systématique s’explique peut-être par le peu de prestige qui, aujourd’hui malgré tout, recouvre l’écriture destinée aux enfants, comme si l’écriture pour enfants n’était qu’un prélude à la “vraie” écriture et que la poésie pour enfants (considerée comme “simplifiée”) n’était qu’une condition préalable de la “vraie” poésie.Nous pensons donc tout d’abord avoir démontré l’importance de la poésie dans l’enfance même et de sa grande importance dans le processus d’éducation et d’éducation esthétique. A notre avis, la critique ne peut en effet pas être soumise à des principes didactiques ou moraux, mais doit tenir compte de cette démarche artistique : le recueil de poésie pour enfants doit donc satisfaire ses besoins (curiosité, jeu, besoin de s’exprimer) et constituent en même temps un véritable pont entre l’art, la littérature et la musique. L’apport de disciplines telles que la sociologie, en particulier les réflexions sur la société et la culture dites “liquides” théorisées par Zygmunt Bauman ont enrichi les élaborations proposées.Une autre nouveauté est d’avoir mené une étude sur le genre dans le domaine de la poésie de l’enfance. Bien que non définitive, cette enquête nous a permis d’élargir l’horizon de la critique.Dans le contexte des auteurs, nous pensons avoir eu le mérite de nous rappeler des auteurs peu présents (ou totalement absents) dans les anthologies de poésie pour enfants, tels que Tommaso Landolfi, Giulia Niccolai, Rossana Ombres et Giovanni Arpino et pour avoir revendiqué et réservé espace particulier à Giuseppe Pontremoli et Pierluigi Cappello. Dans le contexte des anthologies, nous pensons également, à juste titre, que nous avons inclus l’analyse (et l’évaluation) d’anthologies pour enfants dans l’étude de l’anthologie poétique (en particulier celles de Roberto Antonelli dans « Critica del testo » et Niccolò Scaffai), une opération complètement nouvelle. L’anthologie proposée suit donc les critères mis en évidence et diffère considérablement de celles du passé et de celles actuellement sur le marché

A CT-based transfer learning approach to predict NSCLC recurrence: The added-value of peritumoral region.

Non-small cell lung cancer (NSCLC) represents 85% of all new lung cancer diagnoses and presents a high recurrence rate after surgery. Thus, an accurate prediction of recurrence risk in NSCLC patients at diagnosis could be essential to designate risk patients to more aggressive medical treatments. In this manuscript, we apply a transfer learning approach to predict recurrence in NSCLC patients, exploiting only data acquired during its screening phase. Particularly, we used a public radiogenomic dataset of NSCLC patients having a primary tumor CT image and clinical information. Starting from the CT slice containing the tumor with maximum area, we considered three different dilatation sizes to identify three Regions of Interest (ROIs): CROP (without dilation), CROP 10 and CROP 20. Then, from each ROI, we extracted radiomic features by means of different pre-trained CNNs. The latter have been combined with clinical information; thus, we trained a Support Vector Machine classifier to predict the NSCLC recurrence. The classification performances of the devised models were finally evaluated on both the hold-out training and hold-out test sets, in which the original sample has been previously divided. The experimental results showed that the model obtained analyzing CROP 20 images, which are the ROIs containing more peritumoral area, achieved the best performances on both the hold-out training set, with an AUC of 0.73, an Accuracy of 0.61, a Sensitivity of 0.63, and a Specificity of 0.60, and on the hold-out test set, with an AUC value of 0.83, an Accuracy value of 0.79, a Sensitivity value of 0.80, and a Specificity value of 0.78. The proposed model represents a promising procedure for early predicting recurrence risk in NSCLC patients

Comparison between vision transformers and convolutional neural networks to predict non-small lung cancer recurrence

Abstract Non-Small cell lung cancer (NSCLC) is one of the most dangerous cancers, with 85% of all new lung cancer diagnoses and a 30–55% of recurrence rate after surgery. Thus, an accurate prediction of recurrence risk in NSCLC patients during diagnosis could be essential to drive targeted therapies preventing either overtreatment or undertreatment of cancer patients. The radiomic analysis of CT images has already shown great potential in solving this task; specifically, Convolutional Neural Networks (CNNs) have already been proposed providing good performances. Recently, Vision Transformers (ViTs) have been introduced, reaching comparable and even better performances than traditional CNNs in image classification. The aim of the proposed paper was to compare the performances of different state-of-the-art deep learning algorithms to predict cancer recurrence in NSCLC patients. In this work, using a public database of 144 patients, we implemented a transfer learning approach, involving different Transformers architectures like pre-trained ViTs, pre-trained Pyramid Vision Transformers, and pre-trained Swin Transformers to predict the recurrence of NSCLC patients from CT images, comparing their performances with state-of-the-art CNNs. Although, the best performances in this study are reached via CNNs with AUC, Accuracy, Sensitivity, Specificity, and Precision equal to 0.91, 0.89, 0.85, 0.90, and 0.78, respectively, Transformer architectures reach comparable ones with AUC, Accuracy, Sensitivity, Specificity, and Precision equal to 0.90, 0.86, 0.81, 0.89, and 0.75, respectively. Based on our preliminary experimental results, it appears that Transformers architectures do not add improvements in terms of predictive performance to the addressed problem

An Invasive Disease Event-Free Survival Analysis to Investigate Ki67 Role with Respect to Breast Cancer Patients’ Age: A Retrospective Cohort Study

Characterization of breast cancer into intrinsic molecular profiles has allowed women to live longer, undergoing personalized treatments. With the aim of investigating the relation between different values of ki67 and the predisposition to develop a breast cancer-related IDE at different ages, we enrolled 900 patients with a first diagnosis of invasive breast cancer, and we partitioned the dataset into two sub-samples with respect to an age value equal to 50 years. For each sample, we performed a Kaplan–Meier analysis to compare the IDE-free survival curves obtained with reference to different ki67 values. The analysis on patients under 50 years old resulted in a p-value < 0.001, highlighting how the behaviors of patients characterized by a ki67 ranging from 10% to 20% and greater than 20% were statistically significantly similar. Conversely, patients over 50 years old characterized by a ki67 ranging from 10% to 20% showed an IDE-free survival probability significantly greater than patients with a ki67 greater than 20%, with a p-value of 0.01. Our work shows that the adoption of two different ki67 values, namely, 10% and 20%, might be discriminant in designing personalized treatments for patients under 50 years old and over 50 years old, respectively

Rime scandite dai tempi del lavoro

Vita lavoro scrittura in Agota Kristof Goliarda Sapienza Nella Nobili: tre autrici he hanno lottato per cancellare un confine che le voleva in un altro luogo a fare altro: Agota rifugiata esule, Goliarda depressa povera, Nella operaia assetata di cultur

Il genio della meraviglia

Raccontare con immagini gli istanti di stupore: un viaggio nel lavoro fotografico di Jacques Henri Lartigu